Patient characteristics, clinical course and factors associated to ICU mortality in critically ill patients infected with SARS-CoV-2 in Spain: A prospective, cohort, multicentre study.
Identifieur interne : 000377 ( Main/Exploration ); précédent : 000376; suivant : 000378Patient characteristics, clinical course and factors associated to ICU mortality in critically ill patients infected with SARS-CoV-2 in Spain: A prospective, cohort, multicentre study.
Auteurs : C. Ferrando [Espagne] ; R. Mellado-Artigas [Espagne] ; A. Gea [Espagne] ; E. Arruti [Espagne] ; C. Aldecoa [Espagne] ; A. Bordell [Espagne] ; R. Adalia [Espagne] ; L. Zattera [Espagne] ; F. Ramasco [Espagne] ; P. Monedero [Espagne] ; E. Maseda [Espagne] ; A. Martínez [Espagne] ; G. Tamayo [Espagne] ; J. Mercadal [Espagne] ; G. Mu Oz [Espagne] ; A. Jacas [Espagne] ; G. Ángeles [Espagne] ; P. Castro [Espagne] ; M. Hernández-Tejero [Espagne] ; J. Fernandez [Espagne] ; M. G Mez-Rojo [Espagne] ; Á Candela [Espagne] ; J. Ripollés [Espagne] ; A. Nieto [Espagne] ; E. Bassas [Espagne] ; C. Deiros [Espagne] ; A. Margarit [Espagne] ; F J Redondo [Andorre] ; A. Martín [Espagne] ; N. García [Espagne] ; P. Casas [Espagne] ; C. Morcillo [Espagne] ; M L Hernández-Sanz [Espagne]Source :
- Revista espanola de anestesiologia y reanimacion [ 2340-3284 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Analyse de régression (MeSH), Andorre (épidémiologie), Antiviraux (usage thérapeutique), Atteinte rénale aigüe (épidémiologie), Betacoronavirus (MeSH), Choc (épidémiologie), Durée du séjour (MeSH), Espagne (épidémiologie), Facteurs de risque (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Humains (MeSH), Hypoxie (épidémiologie), Indice APACHE (MeSH), Infections à coronavirus (complications), Infections à coronavirus (mortalité), Infections à coronavirus (sang), Infections à coronavirus (thérapie), Maladie grave (MeSH), Mortalité hospitalière (MeSH), Mâle (MeSH), Odds ratio (MeSH), Oxygène (administration et posologie), Pandémies (MeSH), Pneumopathie virale (complications), Pneumopathie virale (mortalité), Pneumopathie virale (sang), Pneumopathie virale (thérapie), Sujet âgé (MeSH), Syndrome respiratoire aigu sévère (épidémiologie), Thérapie respiratoire (méthodes), Troubles du rythme cardiaque (épidémiologie), Unités de soins intensifs (statistiques et données numériques), Études prospectives (MeSH).
- MESH :
- administration et posologie : Oxygène.
- mortalité : Infections à coronavirus, Pneumopathie virale.
- méthodes : Thérapie respiratoire.
- sang : Infections à coronavirus, Pneumopathie virale.
- statistiques et données numériques : Unités de soins intensifs.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Antiviraux.
- épidémiologie : Andorre, Atteinte rénale aigüe, Choc, Espagne, Hypoxie, Syndrome respiratoire aigu sévère, Troubles du rythme cardiaque.
- Adulte d'âge moyen, Analyse de régression, Betacoronavirus, Durée du séjour, Facteurs de risque, Facteurs âges, Femelle, Humains, Indice APACHE, Maladie grave, Mortalité hospitalière, Mâle, Odds ratio, Pandémies, Sujet âgé, Études prospectives.
- Wicri :
English descriptors
- KwdEn :
- APACHE (MeSH), Acute Kidney Injury (epidemiology), Age Factors (MeSH), Aged (MeSH), Andorra (epidemiology), Antiviral Agents (therapeutic use), Arrhythmias, Cardiac (epidemiology), Betacoronavirus (MeSH), Coronavirus Infections (blood), Coronavirus Infections (complications), Coronavirus Infections (mortality), Coronavirus Infections (therapy), Critical Illness (MeSH), Female (MeSH), Hospital Mortality (MeSH), Humans (MeSH), Hypoxia (epidemiology), Intensive Care Units (statistics & numerical data), Length of Stay (MeSH), Male (MeSH), Middle Aged (MeSH), Odds Ratio (MeSH), Oxygen (administration & dosage), Pandemics (MeSH), Pneumonia, Viral (blood), Pneumonia, Viral (complications), Pneumonia, Viral (mortality), Pneumonia, Viral (therapy), Prospective Studies (MeSH), Regression Analysis (MeSH), Respiratory Therapy (methods), Risk Factors (MeSH), Severe Acute Respiratory Syndrome (epidemiology), Shock (epidemiology), Spain (epidemiology).
- MESH :
- chemical , administration & dosage : Oxygen.
- chemical , therapeutic use : Antiviral Agents.
- geographic , epidemiology : Andorra, Spain.
- blood : Coronavirus Infections, Pneumonia, Viral.
- complications : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Acute Kidney Injury, Arrhythmias, Cardiac, Hypoxia, Severe Acute Respiratory Syndrome, Shock.
- methods : Respiratory Therapy.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- statistics & numerical data : Intensive Care Units.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- APACHE, Age Factors, Aged, Betacoronavirus, Critical Illness, Female, Hospital Mortality, Humans, Length of Stay, Male, Middle Aged, Odds Ratio, Pandemics, Prospective Studies, Regression Analysis, Risk Factors.
Abstract
BACKGROUND
The clinical course of COVID-19 critically ill patients, during their admission in the intensive care unit (UCI), including medical and infectious complications and support therapies, as well as their association with in-ICU mortality has not been fully reported.
OBJECTIVE
This study aimed to describe clinical characteristics and clinical course of ICU COVID-19 patients, and to determine risk factors for ICU mortality of COVID-19 patients.
METHODS
Prospective, multicentre, cohort study that enrolled critically ill COVID-19 patients admitted into 30 ICUs from Spain and Andorra. Consecutive patients from March 12
RESULTS
A total of 663 patients were included. Overall ICU mortality was 31% (203 patients). At ICU admission non-survivors were more hypoxemic [SpO
CONCLUSIONS
Older COVID-19 patients with higher APACHE II scores on admission, those who developed AKI grades ii or iii and/or septic shock during ICU stay had an increased risk-of-death. ICU mortality was 31%.
DOI: 10.1016/j.redar.2020.07.003
PubMed: 32800622
PubMed Central: PMC7357496
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Gea</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Medicina Preventiva y Salud Pública, Escuela Médica, Universidad de Navarra, Pamplona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Medicina Preventiva y Salud Pública, Escuela Médica, Universidad de Navarra, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Arruti, E" sort="Arruti, E" uniqKey="Arruti E" first="E" last="Arruti">E. Arruti</name><affiliation wicri:level="1"><nlm:affiliation>Tecnología Ubikare, Bilbao, Vizcaya, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Tecnología Ubikare, Bilbao, Vizcaya</wicri:regionArea><wicri:noRegion>Vizcaya</wicri:noRegion></affiliation></author><author><name sortKey="Aldecoa, C" sort="Aldecoa, C" uniqKey="Aldecoa C" first="C" last="Aldecoa">C. Aldecoa</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario Río Hortega, Valladolid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario Río Hortega, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Bordell, A" sort="Bordell, A" uniqKey="Bordell A" first="A" last="Bordell">A. Bordell</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario Río Hortega, Valladolid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario Río Hortega, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Adalia, R" sort="Adalia, R" uniqKey="Adalia R" first="R" last="Adalia">R. Adalia</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Mar, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital del Mar, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Zattera, L" sort="Zattera, L" uniqKey="Zattera L" first="L" last="Zattera">L. Zattera</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Mar, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital del Mar, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Ramasco, F" sort="Ramasco, F" uniqKey="Ramasco F" first="F" last="Ramasco">F. Ramasco</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital La Princesa, Madrid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital La Princesa, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Monedero, P" sort="Monedero, P" uniqKey="Monedero P" first="P" last="Monedero">P. Monedero</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínica Universidad de Navarra, Pamplona, Navarra, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínica Universidad de Navarra, Pamplona, Navarra</wicri:regionArea><wicri:noRegion>Navarra</wicri:noRegion></affiliation></author><author><name sortKey="Maseda, E" sort="Maseda, E" uniqKey="Maseda E" first="E" last="Maseda">E. Maseda</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario La Paz, Madrid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario La Paz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Martinez, A" sort="Martinez, A" uniqKey="Martinez A" first="A" last="Martínez">A. Martínez</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital de Cruces, Barakaldo, Vizcaya, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital de Cruces, Barakaldo, Vizcaya</wicri:regionArea><wicri:noRegion>Vizcaya</wicri:noRegion></affiliation></author><author><name sortKey="Tamayo, G" sort="Tamayo, G" uniqKey="Tamayo G" first="G" last="Tamayo">G. Tamayo</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital de Cruces, Barakaldo, Vizcaya, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital de Cruces, Barakaldo, Vizcaya</wicri:regionArea><wicri:noRegion>Vizcaya</wicri:noRegion></affiliation></author><author><name sortKey="Mercadal, J" sort="Mercadal, J" uniqKey="Mercadal J" first="J" last="Mercadal">J. Mercadal</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Mu Oz, G" sort="Mu Oz, G" uniqKey="Mu Oz G" first="G" last="Mu Oz">G. Mu Oz</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Jacas, A" sort="Jacas, A" uniqKey="Jacas A" first="A" last="Jacas">A. Jacas</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Angeles, G" sort="Angeles, G" uniqKey="Angeles G" first="G" last="Ángeles">G. Ángeles</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Castro, P" sort="Castro, P" uniqKey="Castro P" first="P" last="Castro">P. Castro</name><affiliation wicri:level="3"><nlm:affiliation>Unidad de Cuidados Intensivos Médicos, Hospital Clínic, Institut D'investigació August Pi i Sunyer (IDIBAPS), Universidad de Barcelona, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Cuidados Intensivos Médicos, Hospital Clínic, Institut D'investigació August Pi i Sunyer (IDIBAPS), Universidad de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Hernandez Tejero, M" sort="Hernandez Tejero, M" uniqKey="Hernandez Tejero M" first="M" last="Hernández-Tejero">M. Hernández-Tejero</name><affiliation wicri:level="3"><nlm:affiliation>Unidad Hepática, Hospital Clínic, Universidad de Barcelona, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad Hepática, Hospital Clínic, Universidad de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Fernandez, J" sort="Fernandez, J" uniqKey="Fernandez J" first="J" last="Fernandez">J. Fernandez</name><affiliation wicri:level="3"><nlm:affiliation>Unidad Hepática, Hospital Clínic, Universidad de Barcelona, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad Hepática, Hospital Clínic, Universidad de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="G Mez Rojo, M" sort="G Mez Rojo, M" uniqKey="G Mez Rojo M" first="M" last="G Mez-Rojo">M. G Mez-Rojo</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Ramón y Cajal, Madrid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital del Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Candela, A" sort="Candela, A" uniqKey="Candela A" first="Á" last="Candela">Á Candela</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Ramón y Cajal, Madrid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital del Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Ripolles, J" sort="Ripolles, J" uniqKey="Ripolles J" first="J" last="Ripollés">J. Ripollés</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Universitario Infanta Leonor, Madrid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital del Universitario Infanta Leonor, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Nieto, A" sort="Nieto, A" uniqKey="Nieto A" first="A" last="Nieto">A. Nieto</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Universitario Infanta Leonor, Madrid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital del Universitario Infanta Leonor, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bassas, E" sort="Bassas, E" uniqKey="Bassas E" first="E" last="Bassas">E. Bassas</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital San Joan Despí Moises Broggi, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital San Joan Despí Moises Broggi, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Deiros, C" sort="Deiros, C" uniqKey="Deiros C" first="C" last="Deiros">C. Deiros</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital San Joan Despí Moises Broggi, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital San Joan Despí Moises Broggi, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Margarit, A" sort="Margarit, A" uniqKey="Margarit A" first="A" last="Margarit">A. Margarit</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Mar, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital del Mar, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Redondo, F J" sort="Redondo, F J" uniqKey="Redondo F" first="F J" last="Redondo">F J Redondo</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Nostra Senyora de Meritxell SAAS, Andorra, Andorra.</nlm:affiliation><country xml:lang="fr">Andorre</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Nostra Senyora de Meritxell SAAS, Andorra</wicri:regionArea><wicri:noRegion>Andorra</wicri:noRegion></affiliation></author><author><name sortKey="Martin, A" sort="Martin, A" uniqKey="Martin A" first="A" last="Martín">A. Martín</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital de Ciudad Real, Ciudad Real, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital de Ciudad Real, Ciudad Real</wicri:regionArea><wicri:noRegion>Ciudad Real</wicri:noRegion></affiliation></author><author><name sortKey="Garcia, N" sort="Garcia, N" uniqKey="Garcia N" first="N" last="García">N. García</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital de Urdúliz, Urdúliz, Vizcaya, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital de Urdúliz, Urdúliz, Vizcaya</wicri:regionArea><wicri:noRegion>Vizcaya</wicri:noRegion></affiliation></author><author><name sortKey="Casas, P" sort="Casas, P" uniqKey="Casas P" first="P" last="Casas">P. Casas</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital de Terrasa, Terrasa, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital de Terrasa, Terrasa, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Morcillo, C" sort="Morcillo, C" uniqKey="Morcillo C" first="C" last="Morcillo">C. Morcillo</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario a Coruña, A Coruña, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario a Coruña, A Coruña</wicri:regionArea><wicri:noRegion>A Coruña</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez Sanz, M L" sort="Hernandez Sanz, M L" uniqKey="Hernandez Sanz M" first="M L" last="Hernández-Sanz">M L Hernández-Sanz</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Sanitas CIMA, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Sanitas CIMA, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32800622</idno><idno type="pmid">32800622</idno><idno type="doi">10.1016/j.redar.2020.07.003</idno><idno type="pmc">PMC7357496</idno><idno type="wicri:Area/Main/Corpus">000623</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000623</idno><idno type="wicri:Area/Main/Curation">000623</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000623</idno><idno type="wicri:Area/Main/Exploration">000623</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Patient characteristics, clinical course and factors associated to ICU mortality in critically ill patients infected with SARS-CoV-2 in Spain: A prospective, cohort, multicentre study.</title><author><name sortKey="Ferrando, C" sort="Ferrando, C" uniqKey="Ferrando C" first="C" last="Ferrando">C. Ferrando</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, España. Electronic address: cafeoranestesia@gmail.com.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Mellado Artigas, R" sort="Mellado Artigas, R" uniqKey="Mellado Artigas R" first="R" last="Mellado-Artigas">R. Mellado-Artigas</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Gea, A" sort="Gea, A" uniqKey="Gea A" first="A" last="Gea">A. Gea</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Medicina Preventiva y Salud Pública, Escuela Médica, Universidad de Navarra, Pamplona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Medicina Preventiva y Salud Pública, Escuela Médica, Universidad de Navarra, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Arruti, E" sort="Arruti, E" uniqKey="Arruti E" first="E" last="Arruti">E. Arruti</name><affiliation wicri:level="1"><nlm:affiliation>Tecnología Ubikare, Bilbao, Vizcaya, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Tecnología Ubikare, Bilbao, Vizcaya</wicri:regionArea><wicri:noRegion>Vizcaya</wicri:noRegion></affiliation></author><author><name sortKey="Aldecoa, C" sort="Aldecoa, C" uniqKey="Aldecoa C" first="C" last="Aldecoa">C. Aldecoa</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario Río Hortega, Valladolid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario Río Hortega, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Bordell, A" sort="Bordell, A" uniqKey="Bordell A" first="A" last="Bordell">A. Bordell</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario Río Hortega, Valladolid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario Río Hortega, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Adalia, R" sort="Adalia, R" uniqKey="Adalia R" first="R" last="Adalia">R. Adalia</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Mar, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital del Mar, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Zattera, L" sort="Zattera, L" uniqKey="Zattera L" first="L" last="Zattera">L. Zattera</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Mar, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital del Mar, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Ramasco, F" sort="Ramasco, F" uniqKey="Ramasco F" first="F" last="Ramasco">F. Ramasco</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital La Princesa, Madrid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital La Princesa, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Monedero, P" sort="Monedero, P" uniqKey="Monedero P" first="P" last="Monedero">P. Monedero</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínica Universidad de Navarra, Pamplona, Navarra, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínica Universidad de Navarra, Pamplona, Navarra</wicri:regionArea><wicri:noRegion>Navarra</wicri:noRegion></affiliation></author><author><name sortKey="Maseda, E" sort="Maseda, E" uniqKey="Maseda E" first="E" last="Maseda">E. Maseda</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario La Paz, Madrid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario La Paz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Martinez, A" sort="Martinez, A" uniqKey="Martinez A" first="A" last="Martínez">A. Martínez</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital de Cruces, Barakaldo, Vizcaya, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital de Cruces, Barakaldo, Vizcaya</wicri:regionArea><wicri:noRegion>Vizcaya</wicri:noRegion></affiliation></author><author><name sortKey="Tamayo, G" sort="Tamayo, G" uniqKey="Tamayo G" first="G" last="Tamayo">G. Tamayo</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital de Cruces, Barakaldo, Vizcaya, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital de Cruces, Barakaldo, Vizcaya</wicri:regionArea><wicri:noRegion>Vizcaya</wicri:noRegion></affiliation></author><author><name sortKey="Mercadal, J" sort="Mercadal, J" uniqKey="Mercadal J" first="J" last="Mercadal">J. Mercadal</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Mu Oz, G" sort="Mu Oz, G" uniqKey="Mu Oz G" first="G" last="Mu Oz">G. Mu Oz</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Jacas, A" sort="Jacas, A" uniqKey="Jacas A" first="A" last="Jacas">A. Jacas</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Angeles, G" sort="Angeles, G" uniqKey="Angeles G" first="G" last="Ángeles">G. Ángeles</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Castro, P" sort="Castro, P" uniqKey="Castro P" first="P" last="Castro">P. Castro</name><affiliation wicri:level="3"><nlm:affiliation>Unidad de Cuidados Intensivos Médicos, Hospital Clínic, Institut D'investigació August Pi i Sunyer (IDIBAPS), Universidad de Barcelona, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Cuidados Intensivos Médicos, Hospital Clínic, Institut D'investigació August Pi i Sunyer (IDIBAPS), Universidad de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Hernandez Tejero, M" sort="Hernandez Tejero, M" uniqKey="Hernandez Tejero M" first="M" last="Hernández-Tejero">M. Hernández-Tejero</name><affiliation wicri:level="3"><nlm:affiliation>Unidad Hepática, Hospital Clínic, Universidad de Barcelona, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad Hepática, Hospital Clínic, Universidad de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Fernandez, J" sort="Fernandez, J" uniqKey="Fernandez J" first="J" last="Fernandez">J. Fernandez</name><affiliation wicri:level="3"><nlm:affiliation>Unidad Hepática, Hospital Clínic, Universidad de Barcelona, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad Hepática, Hospital Clínic, Universidad de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="G Mez Rojo, M" sort="G Mez Rojo, M" uniqKey="G Mez Rojo M" first="M" last="G Mez-Rojo">M. G Mez-Rojo</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Ramón y Cajal, Madrid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital del Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Candela, A" sort="Candela, A" uniqKey="Candela A" first="Á" last="Candela">Á Candela</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Ramón y Cajal, Madrid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital del Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Ripolles, J" sort="Ripolles, J" uniqKey="Ripolles J" first="J" last="Ripollés">J. Ripollés</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Universitario Infanta Leonor, Madrid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital del Universitario Infanta Leonor, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Nieto, A" sort="Nieto, A" uniqKey="Nieto A" first="A" last="Nieto">A. Nieto</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Universitario Infanta Leonor, Madrid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital del Universitario Infanta Leonor, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bassas, E" sort="Bassas, E" uniqKey="Bassas E" first="E" last="Bassas">E. Bassas</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital San Joan Despí Moises Broggi, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital San Joan Despí Moises Broggi, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Deiros, C" sort="Deiros, C" uniqKey="Deiros C" first="C" last="Deiros">C. Deiros</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital San Joan Despí Moises Broggi, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital San Joan Despí Moises Broggi, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Margarit, A" sort="Margarit, A" uniqKey="Margarit A" first="A" last="Margarit">A. Margarit</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Mar, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital del Mar, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Redondo, F J" sort="Redondo, F J" uniqKey="Redondo F" first="F J" last="Redondo">F J Redondo</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Nostra Senyora de Meritxell SAAS, Andorra, Andorra.</nlm:affiliation><country xml:lang="fr">Andorre</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Nostra Senyora de Meritxell SAAS, Andorra</wicri:regionArea><wicri:noRegion>Andorra</wicri:noRegion></affiliation></author><author><name sortKey="Martin, A" sort="Martin, A" uniqKey="Martin A" first="A" last="Martín">A. Martín</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital de Ciudad Real, Ciudad Real, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital de Ciudad Real, Ciudad Real</wicri:regionArea><wicri:noRegion>Ciudad Real</wicri:noRegion></affiliation></author><author><name sortKey="Garcia, N" sort="Garcia, N" uniqKey="Garcia N" first="N" last="García">N. García</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital de Urdúliz, Urdúliz, Vizcaya, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital de Urdúliz, Urdúliz, Vizcaya</wicri:regionArea><wicri:noRegion>Vizcaya</wicri:noRegion></affiliation></author><author><name sortKey="Casas, P" sort="Casas, P" uniqKey="Casas P" first="P" last="Casas">P. Casas</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital de Terrasa, Terrasa, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital de Terrasa, Terrasa, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Morcillo, C" sort="Morcillo, C" uniqKey="Morcillo C" first="C" last="Morcillo">C. Morcillo</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario a Coruña, A Coruña, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario a Coruña, A Coruña</wicri:regionArea><wicri:noRegion>A Coruña</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez Sanz, M L" sort="Hernandez Sanz, M L" uniqKey="Hernandez Sanz M" first="M L" last="Hernández-Sanz">M L Hernández-Sanz</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Sanitas CIMA, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Anestesiología y Cuidados Críticos, Hospital Sanitas CIMA, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></analytic><series><title level="j">Revista espanola de anestesiologia y reanimacion</title><idno type="eISSN">2340-3284</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>APACHE (MeSH)</term><term>Acute Kidney Injury (epidemiology)</term><term>Age Factors (MeSH)</term><term>Aged (MeSH)</term><term>Andorra (epidemiology)</term><term>Antiviral Agents (therapeutic use)</term><term>Arrhythmias, Cardiac (epidemiology)</term><term>Betacoronavirus (MeSH)</term><term>Coronavirus Infections (blood)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (therapy)</term><term>Critical Illness (MeSH)</term><term>Female (MeSH)</term><term>Hospital Mortality (MeSH)</term><term>Humans (MeSH)</term><term>Hypoxia (epidemiology)</term><term>Intensive Care Units (statistics & numerical data)</term><term>Length of Stay (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Odds Ratio (MeSH)</term><term>Oxygen (administration & dosage)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (blood)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (therapy)</term><term>Prospective Studies (MeSH)</term><term>Regression Analysis (MeSH)</term><term>Respiratory Therapy (methods)</term><term>Risk Factors (MeSH)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Shock (epidemiology)</term><term>Spain (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Analyse de régression (MeSH)</term><term>Andorre (épidémiologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Atteinte rénale aigüe (épidémiologie)</term><term>Betacoronavirus (MeSH)</term><term>Choc (épidémiologie)</term><term>Durée du séjour (MeSH)</term><term>Espagne (épidémiologie)</term><term>Facteurs de risque (MeSH)</term><term>Facteurs âges (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Hypoxie (épidémiologie)</term><term>Indice APACHE (MeSH)</term><term>Infections à coronavirus (complications)</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (sang)</term><term>Infections à coronavirus (thérapie)</term><term>Maladie grave (MeSH)</term><term>Mortalité hospitalière (MeSH)</term><term>Mâle (MeSH)</term><term>Odds ratio (MeSH)</term><term>Oxygène (administration et posologie)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (complications)</term><term>Pneumopathie virale (mortalité)</term><term>Pneumopathie virale (sang)</term><term>Pneumopathie virale (thérapie)</term><term>Sujet âgé (MeSH)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Thérapie respiratoire (méthodes)</term><term>Troubles du rythme cardiaque (épidémiologie)</term><term>Unités de soins intensifs (statistiques et données numériques)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Andorra</term><term>Spain</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Oxygène</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Acute Kidney Injury</term><term>Arrhythmias, Cardiac</term><term>Hypoxia</term><term>Severe Acute Respiratory Syndrome</term><term>Shock</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Respiratory Therapy</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Thérapie respiratoire</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Intensive Care Units</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Unités de soins intensifs</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Andorre</term><term>Atteinte rénale aigüe</term><term>Choc</term><term>Espagne</term><term>Hypoxie</term><term>Syndrome respiratoire aigu sévère</term><term>Troubles du rythme cardiaque</term></keywords><keywords scheme="MESH" xml:lang="en"><term>APACHE</term><term>Age Factors</term><term>Aged</term><term>Betacoronavirus</term><term>Critical Illness</term><term>Female</term><term>Hospital Mortality</term><term>Humans</term><term>Length of Stay</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Pandemics</term><term>Prospective Studies</term><term>Regression Analysis</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse de régression</term><term>Betacoronavirus</term><term>Durée du séjour</term><term>Facteurs de risque</term><term>Facteurs âges</term><term>Femelle</term><term>Humains</term><term>Indice APACHE</term><term>Maladie grave</term><term>Mortalité hospitalière</term><term>Mâle</term><term>Odds ratio</term><term>Pandémies</term><term>Sujet âgé</term><term>Études prospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Andorre</term><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>The clinical course of COVID-19 critically ill patients, during their admission in the intensive care unit (UCI), including medical and infectious complications and support therapies, as well as their association with in-ICU mortality has not been fully reported.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>This study aimed to describe clinical characteristics and clinical course of ICU COVID-19 patients, and to determine risk factors for ICU mortality of COVID-19 patients.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Prospective, multicentre, cohort study that enrolled critically ill COVID-19 patients admitted into 30 ICUs from Spain and Andorra. Consecutive patients from March 12</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>A total of 663 patients were included. Overall ICU mortality was 31% (203 patients). At ICU admission non-survivors were more hypoxemic [SpO</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Older COVID-19 patients with higher APACHE II scores on admission, those who developed AKI grades ii or iii and/or septic shock during ICU stay had an increased risk-of-death. ICU mortality was 31%.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32800622</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>07</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2340-3284</ISSN><JournalIssue CitedMedium="Internet"><Volume>67</Volume><Issue>8</Issue><PubDate><Year>2020</Year><Month>10</Month></PubDate></JournalIssue><Title>Revista espanola de anestesiologia y reanimacion</Title><ISOAbbreviation>Rev Esp Anestesiol Reanim</ISOAbbreviation></Journal><ArticleTitle>Patient characteristics, clinical course and factors associated to ICU mortality in critically ill patients infected with SARS-CoV-2 in Spain: A prospective, cohort, multicentre study.</ArticleTitle><Pagination><MedlinePgn>425-437</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0034-9356(20)30187-0</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.redar.2020.07.003</ELocationID><Abstract><AbstractText Label="BACKGROUND">The clinical course of COVID-19 critically ill patients, during their admission in the intensive care unit (UCI), including medical and infectious complications and support therapies, as well as their association with in-ICU mortality has not been fully reported.</AbstractText><AbstractText Label="OBJECTIVE">This study aimed to describe clinical characteristics and clinical course of ICU COVID-19 patients, and to determine risk factors for ICU mortality of COVID-19 patients.</AbstractText><AbstractText Label="METHODS">Prospective, multicentre, cohort study that enrolled critically ill COVID-19 patients admitted into 30 ICUs from Spain and Andorra. Consecutive patients from March 12<sup>th</sup> to May 26<sup>th</sup>, 2020 were enrolled if they had died or were discharged from ICU during the study period. Demographics, symptoms, vital signs, laboratory markers, supportive therapies, pharmacological treatments, medical and infectious complications were reported and compared between deceased and discharged patients.</AbstractText><AbstractText Label="RESULTS">A total of 663 patients were included. Overall ICU mortality was 31% (203 patients). At ICU admission non-survivors were more hypoxemic [SpO<sub>2</sub> with non-rebreather mask, 90 (IQR 83 to 93) vs. 91 (IQR 87 to 94); P<.001] and with higher sequential organ failure assessment score [SOFA, 7 (IQR 5 to 9) vs. 4 (IQR 3 to 7); P<.001]. Complications were more frequent in non-survivors: acute respiratory distress syndrome (ARDS) (95% vs. 89%; P=.009), acute kidney injury (AKI) (58% vs. 24%; P<10<sup>-16</sup>), shock (42% vs. 14%; P<10<sup>-13</sup>), and arrhythmias (24% vs. 11%; P<10<sup>-4</sup>). Respiratory super-infection, bloodstream infection and septic shock were higher in non-survivors (33% vs. 25%; P=.03, 33% vs. 23%; P=.01 and 15% vs. 3%, P=10<sup>-7</sup>), respectively. The multivariable regression model showed that age was associated with mortality, with every year increasing risk-of-death by 1% (95%CI: 1 to 10, P=.014). Each 5-point increase in APACHE II independently predicted mortality [OR: 1.508 (1.081, 2.104), P=.015]. Patients with AKI [OR: 2.468 (1.628, 3.741), P<10<sup>-4</sup>)], cardiac arrest [OR: 11.099 (3.389, 36.353), P=.0001], and septic shock [OR: 3.224 (1.486, 6.994), P=.002] had an increased risk-of-death.</AbstractText><AbstractText Label="CONCLUSIONS">Older COVID-19 patients with higher APACHE II scores on admission, those who developed AKI grades ii or iii and/or septic shock during ICU stay had an increased risk-of-death. ICU mortality was 31%.</AbstractText><CopyrightInformation>Copyright © 2020. Publicado por Elsevier España, S.L.U.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ferrando</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, España. Electronic address: cafeoranestesia@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mellado-Artigas</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gea</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Departamento de Medicina Preventiva y Salud Pública, Escuela Médica, Universidad de Navarra, Pamplona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arruti</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Tecnología Ubikare, Bilbao, Vizcaya, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aldecoa</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario Río Hortega, Valladolid, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bordell</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario Río Hortega, Valladolid, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adalia</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Mar, Barcelona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zattera</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Mar, Barcelona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramasco</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital La Princesa, Madrid, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monedero</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínica Universidad de Navarra, Pamplona, Navarra, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maseda</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario La Paz, Madrid, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martínez</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital de Cruces, Barakaldo, Vizcaya, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tamayo</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital de Cruces, Barakaldo, Vizcaya, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mercadal</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muñoz</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacas</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ángeles</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Barcelona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castro</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Unidad de Cuidados Intensivos Médicos, Hospital Clínic, Institut D'investigació August Pi i Sunyer (IDIBAPS), Universidad de Barcelona, Barcelona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hernández-Tejero</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Unidad Hepática, Hospital Clínic, Universidad de Barcelona, Barcelona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernandez</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Unidad Hepática, Hospital Clínic, Universidad de Barcelona, Barcelona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gómez-Rojo</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Ramón y Cajal, Madrid, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Candela</LastName><ForeName>Á</ForeName><Initials>Á</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Ramón y Cajal, Madrid, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ripollés</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Universitario Infanta Leonor, Madrid, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nieto</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Universitario Infanta Leonor, Madrid, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bassas</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital San Joan Despí Moises Broggi, Barcelona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deiros</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital San Joan Despí Moises Broggi, Barcelona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Margarit</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital del Mar, Barcelona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Redondo</LastName><ForeName>F J</ForeName><Initials>FJ</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Nostra Senyora de Meritxell SAAS, Andorra, Andorra.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martín</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital de Ciudad Real, Ciudad Real, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital de Urdúliz, Urdúliz, Vizcaya, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casas</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital de Terrasa, Terrasa, Barcelona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morcillo</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Universitario a Coruña, A Coruña, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hernández-Sanz</LastName><ForeName>M L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Departamento de Anestesiología y Cuidados Críticos, Hospital Sanitas CIMA, Barcelona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>de la Red de UCI Española para COVID-19</CollectiveName></Author></AuthorList><Language>eng</Language><Language>spa</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType></PublicationTypeList><VernacularTitle>Características, evolución clínica y factores asociados a la mortalidad en UCI de los pacientes críticos infectados por SARS-CoV-2 en España: estudio prospectivo, de cohorte y multicéntrico.</VernacularTitle><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>Spain</Country><MedlineTA>Rev Esp Anestesiol Reanim</MedlineTA><NlmUniqueID>0134516</NlmUniqueID><ISSNLinking>0034-9356</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>S88TT14065</RegistryNumber><NameOfSubstance UI="D010100">Oxygen</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D018806" MajorTopicYN="N">APACHE</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058186" MajorTopicYN="N">Acute Kidney Injury</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000725" MajorTopicYN="N" Type="Geographic">Andorra</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001145" MajorTopicYN="N">Arrhythmias, Cardiac</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016638" MajorTopicYN="N">Critical Illness</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017052" MajorTopicYN="Y">Hospital Mortality</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000860" MajorTopicYN="N">Hypoxia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007902" MajorTopicYN="N">Length of Stay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010100" MajorTopicYN="N">Oxygen</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012044" MajorTopicYN="N">Regression Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012138" MajorTopicYN="N">Respiratory Therapy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012769" MajorTopicYN="N">Shock</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32800622</ArticleId><ArticleId IdType="pii">S0034-9356(20)30187-0</ArticleId><ArticleId IdType="doi">10.1016/j.redar.2020.07.003</ArticleId><ArticleId IdType="pmc">PMC7357496</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Andorre</li><li>Espagne</li></country><region><li>Catalogne</li><li>Communauté de Madrid</li></region><settlement><li>Barcelone</li><li>Madrid</li></settlement></list><tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Ferrando, C" sort="Ferrando, C" uniqKey="Ferrando C" first="C" last="Ferrando">C. Ferrando</name></region><name sortKey="Adalia, R" sort="Adalia, R" uniqKey="Adalia R" first="R" last="Adalia">R. Adalia</name><name sortKey="Aldecoa, C" sort="Aldecoa, C" uniqKey="Aldecoa C" first="C" last="Aldecoa">C. Aldecoa</name><name sortKey="Angeles, G" sort="Angeles, G" uniqKey="Angeles G" first="G" last="Ángeles">G. Ángeles</name><name sortKey="Arruti, E" sort="Arruti, E" uniqKey="Arruti E" first="E" last="Arruti">E. Arruti</name><name sortKey="Bassas, E" sort="Bassas, E" uniqKey="Bassas E" first="E" last="Bassas">E. Bassas</name><name sortKey="Bordell, A" sort="Bordell, A" uniqKey="Bordell A" first="A" last="Bordell">A. Bordell</name><name sortKey="Candela, A" sort="Candela, A" uniqKey="Candela A" first="Á" last="Candela">Á Candela</name><name sortKey="Casas, P" sort="Casas, P" uniqKey="Casas P" first="P" last="Casas">P. Casas</name><name sortKey="Castro, P" sort="Castro, P" uniqKey="Castro P" first="P" last="Castro">P. Castro</name><name sortKey="Deiros, C" sort="Deiros, C" uniqKey="Deiros C" first="C" last="Deiros">C. Deiros</name><name sortKey="Fernandez, J" sort="Fernandez, J" uniqKey="Fernandez J" first="J" last="Fernandez">J. Fernandez</name><name sortKey="G Mez Rojo, M" sort="G Mez Rojo, M" uniqKey="G Mez Rojo M" first="M" last="G Mez-Rojo">M. G Mez-Rojo</name><name sortKey="Garcia, N" sort="Garcia, N" uniqKey="Garcia N" first="N" last="García">N. García</name><name sortKey="Gea, A" sort="Gea, A" uniqKey="Gea A" first="A" last="Gea">A. Gea</name><name sortKey="Hernandez Sanz, M L" sort="Hernandez Sanz, M L" uniqKey="Hernandez Sanz M" first="M L" last="Hernández-Sanz">M L Hernández-Sanz</name><name sortKey="Hernandez Tejero, M" sort="Hernandez Tejero, M" uniqKey="Hernandez Tejero M" first="M" last="Hernández-Tejero">M. Hernández-Tejero</name><name sortKey="Jacas, A" sort="Jacas, A" uniqKey="Jacas A" first="A" last="Jacas">A. Jacas</name><name sortKey="Margarit, A" sort="Margarit, A" uniqKey="Margarit A" first="A" last="Margarit">A. Margarit</name><name sortKey="Martin, A" sort="Martin, A" uniqKey="Martin A" first="A" last="Martín">A. Martín</name><name sortKey="Martinez, A" sort="Martinez, A" uniqKey="Martinez A" first="A" last="Martínez">A. Martínez</name><name sortKey="Maseda, E" sort="Maseda, E" uniqKey="Maseda E" first="E" last="Maseda">E. Maseda</name><name sortKey="Mellado Artigas, R" sort="Mellado Artigas, R" uniqKey="Mellado Artigas R" first="R" last="Mellado-Artigas">R. Mellado-Artigas</name><name sortKey="Mercadal, J" sort="Mercadal, J" uniqKey="Mercadal J" first="J" last="Mercadal">J. Mercadal</name><name sortKey="Monedero, P" sort="Monedero, P" uniqKey="Monedero P" first="P" last="Monedero">P. Monedero</name><name sortKey="Morcillo, C" sort="Morcillo, C" uniqKey="Morcillo C" first="C" last="Morcillo">C. Morcillo</name><name sortKey="Mu Oz, G" sort="Mu Oz, G" uniqKey="Mu Oz G" first="G" last="Mu Oz">G. Mu Oz</name><name sortKey="Nieto, A" sort="Nieto, A" uniqKey="Nieto A" first="A" last="Nieto">A. Nieto</name><name sortKey="Ramasco, F" sort="Ramasco, F" uniqKey="Ramasco F" first="F" last="Ramasco">F. Ramasco</name><name sortKey="Ripolles, J" sort="Ripolles, J" uniqKey="Ripolles J" first="J" last="Ripollés">J. Ripollés</name><name sortKey="Tamayo, G" sort="Tamayo, G" uniqKey="Tamayo G" first="G" last="Tamayo">G. Tamayo</name><name sortKey="Zattera, L" sort="Zattera, L" uniqKey="Zattera L" first="L" last="Zattera">L. Zattera</name></country><country name="Andorre"><noRegion><name sortKey="Redondo, F J" sort="Redondo, F J" uniqKey="Redondo F" first="F J" last="Redondo">F J Redondo</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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